Plasma monocytechemotacticprotein–1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation.
Monocyte chemotactic protein-1 (MCP-1), also known as “the chemokine ligand 2” (CCL2), is a monocyte-attractive chemokines produced in the epithelial cells of the lungs. We previously reported an association of an increase in plasma levels of MCP-1 with primary graft dysfunction (PGD) after lung transplantation in a case-control study of extreme phenotypes using multiplex platform.
In this study, we sought to evaluate the role of plasma MCP-1 levels as a biomarker across the full spectrum of PGD. We conducted a prospective cohort study of 108 lung transplant recipients in Lung Transplant Group Results cohort. Plasma MCP-1 levels were measured pretransplantation and 6 and 24 hours after the transplant. The primary outcome was the development of PGD grade 3 within 72 hours of transplantation, with secondary analyzes at the time point of 72 hours.
Multivariable logistic regression was used to evaluate the bully. Thirty subjects (28%) developed PGD. Median MCP-1 was measured at 24 hours post-transplant increased in subjects with PGD (167.95 vs. 103.5 pg / mL, P = 0.04). MCP-1 levels at 24 hours was associated with an increased likelihood of grade 3 PGD after lung transplantation (odds ratio for each 100 pg / mL, 1.24; 95% confidence interval, 1.00 to 1.53) and with grade 3 PGD present at the 72- hour time point (odds ratio for each 100 pg / mL, 1.57; 95% confidence interval, 1.18 to 2.08), independent confusing variables in multivariable analysis.
MCP-1 levels were measured before surgery and 6 hours after transplantation was not significantly associated with PGD. continual increase in MCP-1 levels at 24 hours are biomarkers PGD grade 3 post-transplantation. monocyte chemotaxis may play a role in the pathogenesis of PGD.
Plasma monocytechemotacticprotein–1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation.
monocytes chemotactic protein – one induced protein – one (MCPIP one ) is a novel multifunctional modulator of inflammatory reactions.
general leads to the inflammatory response to the activation of hundreds of genes are transcribed in the order established specialized cells. Transcriptome analysis of monocyte-derived human cells stimulated with IL-1beta or by monocyte chemotactic protein-1 (MCP-1) has led to the identification of genes related to inflammation-ZC3H12A new encoding 599 amino acid chain corresponding to 66- kDa protein. Protein, given the temporary name of MCPIP1 (monocyte chemotactic protein-induced protein-1), is expressed in several human and murine tissues such as bone marrow, spleen, heart and placenta.
In the in vivo study, mice with the gene-encoding inactive MCPIP1 showed growth retardation, lymphadenopathy, splenomegaly and inflammatory symptoms improved. Head of the molecular features MCPIP1 including zinc finger motif, a PIN RNase-like domain and ubiquitin-binding domain. The report from an independent laboratory showed that MCPIP1 can serve also as deubiquitinase a.
Although MCPIP1 considered by some authors as a new transcription factor or factors of angiogenesis modulating cell differentiation or adipogenesis, the main function seems to downregulation of the inflammatory response through at least two independent mechanisms: an increase in cytokine mRNA degradation and inhibition of LPS- and IL -1-induced NF-kappaB signal track. The interference with the activation of NF-kappaB is very complex and includes the interaction with TRAF6 and TANK (UBA) ubiquitin-associated domain MCPIP1.
Description: A competitive ELISA for quantitative measurement of Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Human Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Human Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Human Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Mouse Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Duck Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor ELISA Kit
Description: A competitive ELISA for quantitative measurement of Monkey Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Monkey Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Monkey Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor ELISA Kit
Description: A competitive ELISA for quantitative measurement of Rabbit Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Rabbit Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Rabbit Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Bovine Monocyte chemotactic protein 1/monocyte chemotactic and activating factor ELISA kit
Description: A competitive ELISA for quantitative measurement of Guinea pig Monocyte chemotactic protein 1/monocyte chemotactic and activating factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
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MCPIP1 pure protein reported to degrade specific mRNA and cut K48- and K63-linked polyubiquitin chains. Although some of the structural features and the mechanism of action of MCPIP1 not fully explained yet, important in the regulation of inflammatory reactions has been established.
